2025

• Cisternas-Olmedo, M., Urra-Alvarez, V., Huerta, T. J., Urbina-Muñoz, V., Saavedra, B., Valdés, I., Riquelme, E., Saez, M., Pérez-Arancibia, R., Delporte, C., & Vidal, R. L. (2025). Neuroprotective and gut health benefits of Ugni molinae in preclinical Huntington’s disease models. Experimental Neurobiology, 375, 105679. https://doi.org/10.1016/j.expneurol.2025.114947

• Fernández-Gajardo, R., Urra, H., Sáez, M., Pihán, P., Fonseca, B., Sanchez-Doñas, C., Cavada, G., Tissera, C., Melo, R., Rojas, D., Matamala, J. M., & Hetz, C. (2025). Characterization of the mutational status of high-grade Astrocytomas in a Latin American cohort. Scientific Reports, 15, 5236. https://doi.org/10.1038/s41598-025-06129-z

• Fernández-Olivares, A., Orellana, V. P., Llanquinao, J., Nuñez, G., Pérez-Moreno, P., Contreras-Riquelme, S., Martin, A. J., Mammano, F., Alfaro, I. E., Calderón, J. F., Stehberg, J., Sáez, M. A., & Retamal, M. A. (2025). Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator. Cell Communication and Signaling, 23, 76. https://doi.org/10.1186/s12964-025-02151-w

• García-Bloj, B., Farah Celis, S., Orellana, N. E., de Mayo Glasser, T., Sáez, M. A., Retamal, I. N., Muñoz-Medel, M., Sánchez, C., Pinto, F., Aravena, P., San Martín, C., Sabioncello H., A. C., Garrido Villanueva, M., Sigler Chávez, F., Ríos Leal, J. A., Manque, P. A., Erpel, J. M., Godoy, J. A., & Garrido, M. (2025). A germline variant of ring finger protein 43 in an early onset, treatment-resistant metastatic gastric cancer: a case report. Journal of Gastrointestinal Oncology, 16. https://doi.org/10.21037/jgo-24-423

• Hernández-Monsalves, A. H., Letelier, P., Morales, C., Rojas, E., Saez, M. A., Coña, N., Díaz, J., San Martín, A., Garcés, P., Espinal-Enriquez, J., & Guzmán, N. (2025). A Machine Learning Model for Predicting Intensive Care Unit Admission in Inpatients with COVID-19 Using Clinical Data and Laboratory Biomarkers. Biomedicines, 13(5), 1025. https://doi.org/10.3390/biomedicines13051025

• Lanuza, F., Romero-López, C., Nova-Luna, R., Cuyul-Vásquez, I., Sáez-Venegas, M., Guzmán, N., Díaz-Velis, L., Zamora-Ros, R., Martínez-Huélamo, M., & Andrés-Lacueva, C. (2025). Effect of plant-based foods and (poly)phenol supplementation on gut-microbiota metabolism in participants with overweight or obesity and cardiometabolic risk: a study protocol for a single-blind, parallel and randomised controlled trial. BMJ Open, 15(9), e105461. https://doi.org/10.1136/bmjopen-2024-105461

• Moya-Beltrán, A., Sánchez, C., Bórquez B., C., Reyes T., T., Villanueva D., H., Soto S., C., León G., M., Mieres-Amigo, P., Saez, M. A., Quatrini, R., Martin, A. J. M., & Alburquenque, C. (2025). Characterization of vaginal prokaryotes and eukaryotes microbiota and its link to sexually transmitted infection. Scientific Reports, 15, 6363. https://doi.org/10.1038/s41598-025-14573-0

• Murgas, L., Pollastri, G., Riquelme, E., Sáez, M., & Martin, A. J. M. (2025). Understanding relationships between epigenetic marks and their application to robust assignment of chromatin states. Briefings in Bioinformatics, 26(1), bbae638. https://doi.org/10.1093/bib/bbae638

• Rodriguez, S. G., Cartas-Espinel, I., Villaman, C., Vidal, M., Perez-Palma, E., Espinal-Enriquez, J., Martin, A. J., & Saez, M. A. (2025). Exploring Single-Cell Gene Regulatory Dynamics in Rett Syndrome. bioRxiv. (Manuscrito enviado). https://doi.org/10.1101/2025.10.01.679774

• Villaman, C., Cartas-Espinel, I., Saez, M., & Martin, A. J. M. (2025). Gaining insights into Alzheimer’s Disease by predicting chromatin spatial organization. Bioinformatics Advances. (Artículo aceptado).

2023

• Arancibia-Opazo, S., Contreras-Riquelme, J. S., Sánchez, M., Cisternas-Olmedo, M., Vidal, R. L., Martin, A. J. M., & Sáez, M. A. (2023). Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington’s Disease Models. International Journal of Molecular Sciences, 24(13), 10816. https://doi.org/10.3390/ijms241310816

• Latapiat, V., Saez, M., Pedroso, I., & Martin, A. J. M. (2023). Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective. Frontiers in Genetics, 14, 1221163. https://doi.org/10.3389/fgene.2023.1221163

• Villaman, C., Pollastri, G., Saez, M. A., & Martin, A. J. M. (2023). Benefiting from the intrinsic role of epigenetics to predict patterns of CTCF binding. Computational and Structural Biotechnology Journal, 21, 3121-3130. https://doi.org/10.1016/j.csbj.2023.05.011

2022

• Cisternas-Olmedo, M., Perez, R., Saez, M., Delporte, C., & Vidal, R. L. (2022). A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation and improve motor behavior in models of Huntington’s disease. Planta Medica, 88(15). https://doi.org/10.1055/a-1759-3641

• Pinto, M. P., Muñoz-Medel, M., Retamal, I. N., Bravo, M., Latapiat, V., Córdova-Delgado, M., Hill, C. N., Fernández, M. F., Sánchez, C., Sáez, M. A., Martin, A. J. M., Morales-Pison, S., Fernandez-Ramires, R., García-Bloj, B., Owen, G. I., & Garrido, M. (2022). Differentially Expressed Genes and Signaling Pathways Potentially Involved in Primary Resistance to Chemo-Immunotherapy in Advanced-Stage Gastric Cancer Patients. International Journal of Molecular Sciences, 24(1), 221. https://doi.org/10.3390/ijms24010221

 2025 – 2028

• Sáez, M. (2025–2028). Study of DNA methylation and chromatin accessibility: Effects on CTCF binding in early stages of Huntington’s disease. ANID – FONDECYT Posdoctoral (Proyecto N° 3250632). Rol: Investigador Patrocinante. Enlace al fallo

2024 – 2026

• Guzmán, N. (PI). (2024–2026). Validación de modelos predictivos de COVID-19 y Long-COVID como herramienta de diagnóstico y pronóstico basado en el uso de datos multimodales e Inteligencia artificial: Fortalecimiento de la Salud de Precisión y Ciencia de Datos en la UC Temuco. Línea Grupos de investigación, Universidad Católica de Temuco (Código Nº 2024GI-AH-03). Rol: Coinvestigador.

2023 – 2025

• Sáez, M. (2023–2025). Herramientas de análisis genómico al servicio de la detección y vigilancia de patógenos en áreas críticas del Hospital Centro Asistencial Padre Las Casas. Fondo de Investigación Asociativa con Instituciones de Salud – UCT (Código Nº 2023FIAS-MS-02). Rol: Director.

2023 – 2024

• Bustos, R. (PI). (2023–2024). Implementación del Laboratorio Interdisciplinario en Microbiología Aplicada (LIMA), para avanzar en el trabajo interdisciplinario bajo una mirada de salud integral (One Health). Una propuesta desde la Facultad de Ciencias de la Salud. FEQUIP – UCT (Código Nº 2023FEQUIP-RB-01). Rol: Coinvestigador.

2018 – 2021

• Sáez, M. (2018–2021). Huntingtin as modulator of Polycomb Repressive Complex 2: Physiological and Pathological effects on Ezh1 function in neurons. ANID – FONDECYT de Iniciación (Proyecto N° 11171015). Rol: Director. Ver nómina